Cannabis Smoking and Risk of Lung Cancer - A Systematic Review and Meta-Analysis


Cannabis Smoking
Risk of Lung Cancer
Systematic Review
Possitive Association
Risk Factors


How to Cite

Bouti K, Borki R, Fenane H, Herrak L. Cannabis Smoking and Risk of Lung Cancer - A Systematic Review and Meta-Analysis. Integr J Med Sci [Internet]. 2014 May 14 [cited 2022 Oct. 5];1:31-7. Available from:


Background: Cannabis is the illicit psychoactive substance the most consumed in the world. Little is known about the association between the use of cannabis and the risk of lung cancer.
Objective: The objective of this meta-analysis is to determine whether the use of cannabis is a risk factor for lung cancer.
Methods: We conducted a systematic review and meta-analyses of all language articles using relevant computerized databases. MEDLINE (online PubMed), Web of Knowledge, Embase, EBSCO CINAHL, ScienceDirect, Scopus, Cochrane Library, and Directory of Open Access Journals were searched to September 2014 for cohorts and case-control studies that assessed the risk of lung cancer associated with cannabis smoking.  The literature search was performed with a combination of medical subject headings terms, "cannabis" and "lung neoplasms". Data extraction: Two investigators independently analyzed and extracted results from eligible studies. Our study's registration number on PROSPERO is  CRD42014008872.
Results: The search strategy identified 2476 citations. 13 studies were eligible for inclusion: 2 pooled analyses of 9 case-control studies, one case-control study, and 3 cohorts.
The cumulative analysis for all the studies under a fixed-effects model showed that cannabis smoking determined an increased risk of developing lung cancer in the future (relative risk 1.22, 95% confidence interval 0.999–1.5; p=0.051), with no evidence of heterogeneity across the studies (I2: 34%; p¼0.01).
Conclusions: The use of cannabis with or without tobacco smoking is associated with an increased risk for lung cancer.


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Copyright (c) 2014 Bouti K et al.


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