Effects of Intermittent Cisplatin Intervention on 6PGD Levels and Tumor Growth and Migration in A549 Lung Cancer Cells


Lung cancer
Drug resistance


How to Cite

Qiang W, Lin-dong T, Yan-hui W, Qiang L, Li Y. Effects of Intermittent Cisplatin Intervention on 6PGD Levels and Tumor Growth and Migration in A549 Lung Cancer Cells. Integr J Med Sci [Internet]. 2021 Mar. 15 [cited 2022 May 16];8. Available from: https://www.mbmj.org/index.php/ijms/article/view/442


Aim: To investigate the changes in A549 protein 6PGD expression, tumor growth and migration, NADPH, and ROS levels in lung cancer cells after intermittent intervention with DDP.
Methods: The sensitivity of A549 cells to DDP was detected by the cck-8 method, A549 cells were treated by DDP intermittent, 6PGD protein expression was detected by Western blot method, and the ROS level of A549 cells was determined by ROS kit. NADPH levels of A549 cells were determined by the NADPH kit.
Result: After DDP intermittent intervention, the expression of 6PGD protein in lung cancer cells A549 was increased, the growth and migration of A549 cells were significantly inhibited, and ROS and NADPH levels were significantly increased.
Conclusion: 6PGD were upregulated in after DDP intermittent intervention and affected the migration ability in lung cancer cells.



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