Idiopathic Harlequin Syndrome in a Young Women during Physical Exercise: A Case report and literature review


Harlequin syndrome
Sympathetic nerves
Botulinum toxin


How to Cite

Hajjij A, El Jazouli M, Haddani O, Benariba F. Idiopathic Harlequin Syndrome in a Young Women during Physical Exercise: A Case report and literature review. Integr J Med Sci [Internet]. 2021 Jan. 8 [cited 2022 Jun. 30];8. Available from:


The Harlequin syndrome is a rare and benign disorder of the sympathetic nerves that is mostly idiopathic. It is characterized by an erythema associated with an intense sweating of one side of the face, and a pallor and anhidrosis of the other side. A complete workup to rule out secondary organic causes should be done properly. The medical or surgical options are only required if the patient is in demand of treatment.  Psychological and social impacts of this condition should be considered while consulting patients for treatment options. We report a case of a 24 years old female patient who presented this syndrome during exercise and heat stress. She improved considerably after botulinum toxin injections.


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Copyright (c) 2021 Hajjij A et al.


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